Acute onset dermatomyositis with NXP‐2 antibodies after Sars‐CoV‐2 vaccination in a 20‐year‐old female

Dermatomyositis is an autoimmune connective tissue disease with variable cutaneous and systemic manifestations. While multiple reactions to SARS-CoV-2 vaccination have been described, vaccine-associated emergence of dermatomyositis has rarely reported. Cases deterioration in pre-existing diseases described following both COVID-19 infection. A potential mechanism immune system activation dysregulation suggested. This case describes acute onset a young female, presenting classic features including Gottron papules, Holster sign proximal nail fold erythema, accompanied myalgia fatigue. Laboratory findings elevated creatine kinase myositis-specific autoantibodies confirmed the diagnosis, supportive histological necrotic keratinocytes at dermoepidermal junction. In keeping typical progression NXP-2 autoantibodies, resolved rapidly, while manifestations slowly improved treatment. Thorough investigations for underlying malignancy were completed. adds limited medical literature surrounding these cases further highlights importance consideration immunologic pathophysiology diseases.